不同剂量氟伐他汀调整高脂血症疗效比较  

Fluvastatin of Different Dosages in Management of Hyperlipidemia

作　　者：赵旭[1] 陈自力[1] 郑继平[1] 杨飞[1] 

机构地区：[1]浙江省台州市第一人民医院心内科,浙江黄岩318020

出　　处：《中国药师》2003年第9期572-573,共2页China Pharmacist

摘　　要：目的 :研究不同剂量氟伐他汀调整高脂血症的疗效及不良反应。方法 :氟伐他汀 4 0mgq .n .组 37例 ,2 0mgq .n .组33例 ,服药 4周。结果 :4 0mg组服药后血清总胆固醇降低32 .4 % ,2 0mg组降低15 .7% ,P <0 .0 5。两组降低甘油三酯及升高高密度脂蛋白胆固醇的差异不显著。结论 :氟伐他汀 4 0mgq .n .降低血清总胆固醇的作用明显优于氟伐他汀 2 0mgq .n .。Objective: To investigate effect of fluvastatin of different dosages in the treatment of hyperlipidemia and its side effects.Method: 70 patients were divided into two groups randomly, ie.,37 patients were treated with fluvastatin 40 mg qn and 33 treated with 20 mg qn in controlled group. The duration of treatment was 4 weeks.Result: The level of total cholesterol (TC) decreased by 32.4% in 40 mg qn group, and 15.7% in 20 mg qn group (P< 0.05). The effect of decreasing triglyceride (TG) and increasing high density lipoprotein C (HDL-C) between groups was not significantly different. Conclusion: The effect of fluvastatin 40 mg qn in decreasing TC is superior to that of, fluvastatin 20 mg qn.

关 键 词：氟伐他汀 高脂血症 总胆固醇 疗效 

分 类 号：R972.6[医药卫生—药品]