慢性肾衰患者全段甲状旁腺素的测定及临床意义  

A Significance of Intact Parathyroid Hormone Determination in Patients with Chronic Renal Failure

作　　者：蔡卫民[1] 钱宇锋[2] 马涛[3] 王国洪[4] 赵技文[4] 胡伟新[5] 任红齐[5] 

机构地区：[1]南京军区南京总医院药学部,南京210002 [2]南京大学医学院 [3]徐州医学院 [4]南京军区南京总医院核医学科 [5]南京军区南京总医院肾脏病科

出　　处：《中国药师》2003年第9期529-531,共3页China Pharmacist

基　　金：国家自然科学基金资助 (批准号 :3 0 2 715 2 6);江苏省自然科学基金资助 (批准号 :BK2 0 0 2 0 97)

摘　　要：目的 :探讨慢性肾衰患者全段甲状旁腺素 (iPTH)水平测定的临床意义。方法 :采用免疫放射分析 (IRMA)药盒测定6 0例慢性肾衰 (CRF)患者和 15 2例健康人血浆中iPTH ,同时测定其他血生化指标。结果 :慢性肾衰患者血iPTH较健康志愿者有明显升高 (2 15 .5± 4 2 0 .5vs 4 3.3± 16 .4 pg·ml-1,P <0 .0 5 ) ,健康志愿组中女性iPTH水平又明显高于男性 (4 7.0±17.4vs 39.5± 14 .6pg·ml-1,P <0 .0 5 )。结论 :IRMA法测定血浆iPTH水平准确、可靠 ,是反映慢性肾衰的临床发展重要指标之一。Objective: To determine clinical significance of intact parathyroid hormone(iPTH) assay in patients with chronic renal failure(CRF).Method: Determination of plasma iPTH levels in 60 CRF patients and 152 healthy subjects was done by immunoradiometric assay(IRMA). The other biochemical assays were performed in the same time.Result: iPTH levels in CRF patients were significantly higher than that in healthy subjects( 215.5± 420.5 vs 43.3± 16.4 pg·ml -1, P< 0.05). At mean time, iPTH levels in female healthy subjects were higher than that in male subjects( 47.0± 17.4 vs 39.5± 14.6 pg·ml -1, P< 0.05).Conclusion: IRMA is accurate and reliable in determining iPTH levels. It could be used as one of the important markers in predicting clinical development of CRF.

关 键 词：免疫放射分析法 全段甲状旁腺素 慢性肾衰 

分 类 号：R692.5[医药卫生—泌尿科学] R335.3[医药卫生—外科学]