Liranaftate的傅立叶变换-离子回旋共振质谱研究  

Study on Liranaftate by FT/ICRMS

作　　者：陆豪杰[1] 张芳[1] 郭寅龙[1] 

机构地区：[1]中国科学院上海有机化学研究所,上海200032

出　　处：《质谱学报》2003年第3期403-407,共5页Journal of Chinese Mass Spectrometry Society

摘　　要：用傅立叶变换 -离子回旋共振质谱 (FT/ ICRMS)和傅立叶变换 -离子回旋共振串级质谱 (FT/ ICRMSn,n=2 )研究新药 Liranaftate的裂解机理 ,探讨了相应的碎裂方式和机理 ,发现了该化合物的一个七元环重排裂解规律 ,给出了相应的准确分子量测定数据加以证实 ,同时也对比了 EI和 MAL DI两种不同离子化方式所得到的质谱结果 ,进一步证实了该重排是一个通过 Liranaftate吡啶环上氮原子的七元环重排。The fragmentation mechanism of Liranaftate studied by fourier transform-ion cyclotron resonance mass spectrometry or fourier transform-ion cyclotron resonance tandem mass spectrometry is described. The relatively fragmentation mechanism and pathways are discussed in details. And a rearrangement principle is found by a hepta-atom-ring intermediate. These hypothetical results are confirmed through exact mass measurements, which shows the error between the exact masses and theoretical masses only less than 2 μD, and these mechanisms are further conformed by tandem mass spectrometric experiments. The difference between the mass spectra acquired by MALDI and EI are investigated, and the results are proved that the rearrangements are achieved by a hepta-atom-ring intermediate on the N atom belonged to pyridine ring of Liranaftate.

关 键 词：Liranaftate研究 傅立叶变换-离子回旋共振质谱 抗真菌活性 药物研究 裂解机理 重排反应 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.63[化学工程—制药化工]