化学品(药品)肝毒性的体外筛选试验  

Extrinsic Screening Test for Chemical Hepatotoxicity

作　　者：李立[1] 李克[1] 

机构地区：[1]河南中医学院

出　　处：《河南中医学院学报》2003年第4期36-37,共2页Journal of Henan University of Chinese Medicine

摘　　要：肝毒性是制约化学品 (药品 )开发、生产和应用的重要原因 ,而目前尚缺乏完善的肝毒性预测系统。动物实验数据用于人类是有限的 ,体外实验是对体内肝毒性预测系统很好的完善和补充。目前已用于肝毒性检测的方法为 :肝细胞毒筛选实验 ;基因突变检测 ;共价结合分析 ;毒理基因组学和蛋白基因组学分析。利用分子生物学检测方法来改进和完善现行新药毒性检测手段 。The development, production, and application of chemicals are mainly restricted by hepatotoxicity. There is no sound calculating system yet. Only a limited number of animal experiments have now used, test in vitro is a perfection of and complementation to the calculating of internal hepatotoxicity. Presently used methods are liver cell toxicity screening test, gene mutation test, covalence analysis, and toxicology and protein genome analysis.

关 键 词：化学品(药品) 肝毒性 体外筛选试验 

分 类 号：R595[医药卫生—内科学]