胰敏胶囊阻止高脂膳食诱导大鼠胰岛素抵抗的发生  

Effect of Yimin Capsule in Preventing Insulin Resistance of Rats Induced by High Lipid Diet

作　　者：程海波[1] 尚文斌[1] 司晓晨[1] 

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210029

出　　处：《南京中医药大学学报》2003年第5期281-284,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省教育厅自然科学基金 (99KJB36 0 0 0 1) ;江苏省中医药局资助项目 (992 4)

摘　　要：目的　建立高脂膳食诱导的胰岛素抵抗大鼠模型 ,观察胰敏胶囊对模型大鼠发生胰岛素抵抗的阻止作用。方法　Wistar雄性大鼠分成空白组、模型组、治疗组、对照组 ,治疗组与对照组在以高脂膳食造模的同时 ,每日分别给予胰敏胶囊、罗格列酮 ,每周测血压及体重 ,6周后 ,以正常血糖—高血浆胰岛素钳夹技术 ,结合输注放射性葡萄糖测定股四头肌葡萄糖摄取率评定大鼠的胰岛素敏感性。并测定各组大鼠葡萄糖耐量、血清游离脂肪酸、甘油三酯、血浆胰岛素、胰岛素敏感性指数。结果　与模型组大鼠比较 ,治疗组体重明显下降 ,葡萄糖耐量正常 ,血清甘油三酯、游离脂肪酸、血浆胰岛素含量均显著下降 ,胰岛素敏感性指数、葡萄糖输注率、葡萄糖摄取率升高。治疗组与对照组相比无显著性差异。结论　胰敏胶囊具有阻止高脂膳食诱导的胰岛素抵抗大鼠模型发生胰岛素抵抗的作用。OBJECTIVE To observe the effect of Yimin Capsule in preventing insulin resistance in rat models induced by high lipid diet. METHOD Male Wistar rats were divided into a blank group, a model group, a treatment group and a control group. The blood pressure and body weight were measured each week. After 6 weeks, the sensitivity to insulin was tested by using the clamping technique for normal blood sugar and high blood plasma insulin and by measuring quadriceps glucose absorption rate. The indexes of tolerance of glucose, free fatty acid in serum, triglyceride, plasma insulin, and sensitivity of insulin of rats were also determined. RESULT Compared with the model group, the body weights of rats in the treatment group were reduced markedly, the tolerance to glucose was normal, the contents of serum triglyceride, free fatty acid, and plasma insulin dropped markedly, and the indexes of insulin sensitivity, glucose infusion rate and glucose absorption rate increased. No significant difference was found between the treatment group and the control group. CONCLUSION Yimin Capsule has the effect of preventing insulin resistance in rat models induced by high lipid diet.

关 键 词：胰岛素抵抗 动物模型 高脂膳食 胰敏胶囊 

分 类 号：R285.5[医药卫生—中药学]