Bcl-x基因在紫杉醇诱导的HL-60细胞凋亡过程中的变化  

Change of Bcl-x gene in apoptosis course of HL-60 cells induced by Taxol

作　　者：周兆兰[1] 尤学芬[1] 陆德炎[1] 

机构地区：[1]南通医学院附属医院,江苏南通226001

出　　处：《现代中西医结合杂志》2003年第19期2047-2048,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的　研究抗微管药紫杉醇诱导HL - 6 0细胞凋亡过程中Bcl -x基因表达的变化。方法　用RT -PCR法检测药物孵育前后Bcl-x基因的表达水平。结果　在紫杉醇诱导HL - 6 0细胞凋亡过程中 ,Bcl-x1基因表达水平下降 ,而Bcl-xs 基因表达水平升高。结论　Bcl-x基因参与了紫杉醇诱导的HL - 6 0细胞凋亡的调控。Objective It is to study the change of Bcl-x gene expression in the apoptosis course of HL-60 cells induced by antimicrotubular drug Taxol. Methods Bcl-x gene expression level was examined with RT-PCR technique around drug incubating. Results The expression level of Bcl-x_1 gene decreased while that of Bcl-x_s gene increased in the apoptosis course of HL-60 cells induced by Taxol. Conclusion Bcl-x gene is concerned with the regulation and control of HL-60 cells.

关 键 词：紫杉醇 凋亡 Bcl—x基因 HL—60细胞 

分 类 号：R979.1[医药卫生—药品]