血压调控机制与抗高血压药物靶标  

Modulating mechanisms of blood pressure and targets of antihypertensive drugs

作　　者：殷晓峰[1] 胡刚[2] 汪海[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]南京医科大学药理学与神经生物学系,南京210029

出　　处：《中国药理学通报》2003年第9期971-975,共5页Chinese Pharmacological Bulletin

基　　金：国家重点科技项目攻关计划No 960 10 101

摘　　要：高血压是最常见的慢性病 ,其病因复杂 ,并发症多。抗高血压药物通过影响血压调节系统中一个或多个环节而发挥降低血压、减轻或逆转心血管重构的作用。该文从血压的调节机制出发 ,综述了以肾素 -血管紧张素系统、肾上腺素能系统、缓激肽 -前列腺素系统、血管内皮松弛因子收缩因子系统。Hypertension, which has variant of pathogenesis, is one of the most widely spread chronic diseases with serious complications. Antihypertensive drugs can reduce blood pressure and alleviate or reverse cardiovascular remodeling by affecting one or more processes of blood pressure adjusting system. This review focus on targets of antihypertensive drugs associated with Renin angiotensin system, Adrenergic system, Bradykinin Prostacyclin system, Endothelia factor relative system, iron channels and the progresses in the studies of gene therapy for hypertension.

关 键 词：高血压 抗高血压药物 靶标 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]