塞来昔布治疗骨性膝关节炎的临床观察  

Clinical observation of celecoxib in treatment of osteoarthritis

作　　者：曾少平[1] 彭建民[1] 

机构地区：[1]广东省惠州市中心人民医院中医科,惠州516001

出　　处：《海南医学》2003年第8期19-20,共2页Hainan Medical Journal

摘　　要：目的 评价塞来昔布(celecoxib)治疗骨性膝关节炎的临床疗效和胃肠道不良反应。方法 将68例骨性膝关节炎患者随机分为治疗组36例,每天早晚各服塞来昔布100mg。对照组32例,每天早中晚各服扶他林25mg。疗程4周。结果 采用视觉模拟评分法(VAS)评价两组治疗前后疼痛,均有明显改善(P<0.01)。治疗组有效率91.7％,对照组有效率81.2％(P<0.05),治疗组优于对照组。在不良反应中,治疗组较对照组胃肠道症状发生率低,分别为16.7％和46.9％,统计学有显著性差异(P<0.01)。结论 塞来昔布治疗骨性膝关节炎疗效良好,较传统的非甾体类药物胃肠道不良反应低,提高了临床安全性。Objective To evaluave the eificacv ot ceiecoxib m treatment of osteoarthitis and gastromtestinal side efrects. Methods The randomized study was conducted in 68 patients. There were divided into active arm and control arm. Patients in the active arm were treated with celecoxib in twice daily dose of 100ng for 4 weeks, Patients in the control ann were treated with votalin 25mg for 4 weeks. Results The pain of two arms were graded with VAS prior and post treatment,they were a!l improve. The effective rate was 91.7% for active arm and 81.2% for control arm(P< 0.05), the result of active arm was better than control arm. In the side effects,the incidence of gastrointestinal symptom was 16.7% for active arm and 46.9% for control arm(P<0.01). Conclusions Celecojcib is an effective a靍nt for treatment of osteoarthitis but fewer gastrointestinal side effects in comparision with traditional NSAIDS.

关 键 词：塞来昔布 治疗 骨性膝关节炎 临床观察 疗效 胃肠道不良反应 扶他林 

分 类 号：R684.3[医药卫生—骨科学] R971.1[医药卫生—外科学]