依那普利对急性心肌梗死患者血浆纤溶系统活性和血管紧张素Ⅱ水平的影响  

The effects of enalapril on plasma fibrinolytic system activity and angiotensin Ⅱ level in patients with acute myocardial infarction

作　　者：赵淑健[1] 王士昌[1] 戴华[1] 肖文良[1] 冯忠军[2] 李慧春[3] 刘晓梅[3] 

机构地区：[1]河北医科大学第三医院心内科,050051 [2]河北医科大学第三医院化验室,050051 [3]河北医科大学第三医院同位素科,050051

出　　处：《河北医药》2003年第8期570-571,共2页Hebei Medical Journal

摘　　要：目的　观察依那普利对急性心肌梗死 (AMI)患者组织型血纤维蛋白溶酶原激活物 (t PA)、血纤维蛋白溶酶原激活物抑制物 (PAI)及血管紧张素Ⅱ (AⅡ )水平变化。方法　测定 3 9例AMI患者及2 0名健康人血浆t PA、PAI及AⅡ水平。结果　AMI后血浆t PA水平降低 ,PAI及AⅡ水平升高 ,依那普利可使血浆PAI及AⅡ水平降低 ,t PA水平升高。结论　依那普利可提高血纤溶系统活性 ,降低血浆AⅡ水平。Objective To investigate the changes of plasma tissue plasminogen activator (t PA),plasminogen activator inhibitor (PAI) and angiotensin Ⅱ (AⅡ) level in patients with acute myocardial infarction (AMI) treated by enalapril.Methods The plasma t PA,PAI and AⅡ levels were determined in 39 patients with AMI and in 20 healthy subjects.Results Plasma t PA level was lower,PAI and AⅡ levels were significantly higher in AMI group than that in control group respectively.The enalapril group had a significant decrease of PAI and AⅡ,however it had a increase of t PA level.Conclusion Enalapril has an effect of increasing the activities of fibrinolytic system and decreasing the levels of PAI and AⅡ.

关 键 词：急性心肌梗死 依那普利 纤维蛋白溶酶原激活物 纤维蛋白溶酶原激活物抑制物 血管紧张素Ⅱ 

分 类 号：R542.22[医药卫生—心血管疾病] R972[医药卫生—内科学]