乌索酸对动物实验性肝损伤及胆汁的影响  

Effects of Ursolic Acid on Liver-protection and Bile Secretion

作　　者：熊筱娟[1] 陈蔚云[2] 崔江龙 易少波[1] 张子雯[1] 李开泉[1] 

机构地区：[1]江西宜春学院,宜春336000 [2]江西医学院,南昌330006 [3]江西宜春市第一人民医院,宜春336000

出　　处：《中药材》2003年第8期578-581,共4页Journal of Chinese Medicinal Materials

基　　金：国家高技术研究发展计划 ( 863计划 )资助项目( 2 0 0 2AA2Z3 2 17)

摘　　要：目的 :研究乌索酸保肝利胆作用。方法 :分别以CCl4、APIT制作动物急性肝损伤模型 ,测定血清ALT、AST、SB含量 ,作肝组织病检 ,观察乌索酸对动物急性肝损伤的影响 ;采用麻醉大鼠行胆汁引流术 ,测定正常大鼠及APIT肝损伤大鼠的胆汁分泌量及胆汁成分。结果 :乌索酸能明显降低CCl4、APIT急性肝损伤动物血清ALT、AST水平及SB含量 ,减轻肝组织病理损伤 ;使正常大鼠、APIT肝损伤大鼠的胆汁流量明显增加 ,胆汁中胆红素浓度提高。结论 :乌索酸有明显保肝、利胆作用。Objective: To study the liver protection and promoting bile secretion of ursolic acid Methods: Ursolic acid was administrated to the mice with liver injury induced by CCl 4 or APIT ALT, AST levels in serum were examined The bile flow rate and the concentration of the main components in the bile of rats administrated with ursolic acid were estimated Results: Ursolic acid could decrease the serum ALT, AST, SB levels in the mice treated with CCl 4 or APIT, promote the secretion of bile and increase the concentration of bilirubin in the bile Conclusion: Ursolic acid exhibited significant liver protection and promoting blie secretion

关 键 词：乌索酸 肝损伤 胆汁 实验研究 小鼠 影响 

分 类 号：R285.5[医药卫生—中药学]