煤矿掘进工血浆血管内皮活性物质的测定及意义  

Significance of Measurement of Vascular Endothelial Substances (ET, AT-Ⅱ and CGRP) in Coal Mine Drillers

作　　者：林立[1] 张强[1] 张春之[1] 曾晓立[1] 

机构地区：[1]济宁医学院职业卫生与环境医学研究所,272013

出　　处：《放射免疫学杂志》2003年第4期210-212,共3页Journal of Radioimmanology

摘　　要：目的 :探讨手臂振动对血管内皮活性物质的影响及其意义。方法 :应用放射免疫分析 ,对不同接振时间的煤矿掘进工进行血浆内皮素 (ET)、血管紧张素Ⅱ(AngⅡ)、降钙素基因相关肽 (CGRP)的测定 ,并同对照组进行比较分析。结果 :ET、AngⅡ随接振时间延长有明显增高趋势 (p <0 0 5 ,p <0 0 1) ,CGRP随接振时间延长有显著下降趋势 (p <0 0 1)。结论 :手臂振动可导致血管内皮活性物质的改变 ,这种改变可能与振动性血管损伤、振动性白指有一定联系。Objective To study the effects of hand-arm vibration on the releasing of vascular endothelial substances. Methods The plasma concentrations of endothelin(ET), angiotensin Ⅱ(AngⅡ) and calcitonin gene-related peptide(CGRP) were measured by RIA in coal mine drillers with various vibration-exposed duration. Results With the prolongation of vibration-exposed duration, the plasma concentrations of ET and Ang Ⅱ increased significantly ( p <0 05, p <0 01), whereas the plasma concentrations of CGRP decreased significantly ( p <0 05, p <0 01). Conclusion Long time exposure to hand-arm vibration result in changes of releasing of vascular endothelial substances, which could be related to the vibration-induced vascular impairment and vibration-induced white finger.

关 键 词：煤矿掘进工 血浆 血管内皮活性物质 测定 手臂振动 血管紧张素Ⅱ 内皮素 降钙素基因相关肽 振动性血管损伤 

分 类 号：R135.4[医药卫生—劳动卫生] R446.112[医药卫生—公共卫生与预防医学]