血水草生物碱对鱼类毒性实验的观察  

OBSERVATIONS ON ACUTE TOXICITY OF EOMECON CHIONANTHA HANCE ALKALOIDS TO FISH

作　　者：杨华中[1] 黄琼瑶[1] 彭飞[1] 刘年猛[1] 冯芳[1] 孙慧[1] 

机构地区：[1]湖南师范大学医学院,长沙410006

出　　处：《中国血吸虫病防治杂志》2003年第4期276-278,共3页Chinese Journal of Schistosomiasis Control

基　　金：湖南省科技厅资助项目(编号:00jty1005)

摘　　要：目的 探讨植物杀螺药血水草生物碱(ECA)对鱼类的毒性作用。方法 采用常规的鱼类急性毒性实验方法,分别以氯硝柳胺和清水对照。结果 ①ECA对鲢鱼苗的急性毒性试验,在1.25mg/L及以下浓度中,96h的死亡率为0;在20.0mg/L中,2h死亡率为100％;2h的LC_(50)为6.457mg/L,95％的可信区间为5.289—7.882mg/L。②对鲤鱼苗的急性毒性试验,在2.5mg/L及以下浓度中,96h的死亡率为0;在20.0mg/L中,2h死亡率为100％;2h的LC_(50)为7.244mg/L,95％的可信区间为5.278—9.954mg/L。③对鲫鱼苗的急性毒性试验,在1.25mg/L及以下的浓度中,96h的死亡率为0;在20.0mg/L中,5h死亡率为100％;5h的LC_(50)为7.080mg/L,95％的可信区间为5.202—9.635mg/L。结论 ECA对鲢鱼、鲤鱼、鲫鱼苗急性毒性作用低于氯硝柳胺,在有效杀螺浓度下对鱼毒性低。Objective To understand the acute toxicity of a plant-derived molluscicide Eomecon Chionantha Hance alkaloids ECA to fish. Methods The conventional tests of acute toxicity to fish were carried out at the laboratory. Results The Hypophthalmichthys molitrix mortality was zero under the concentration of 1. 25 mg/L for 96 hours, and 100% under the concentration of 20. 0 mg/ L. for 2 hours. LC50 of ECA to Hypophthalmichthys molitrix was 6. 457 mg/L for 2 h and the 95% confidence interval was 5. 289-7. 882 mg/L. The Cyprinus carpio mortality was zero under the con centration of 2. 5 mg/L for 96 hours, and 100% under the concentration of 20. 0 mg/L for 2 hours. LC50 of ECA to the Cyprinus carpio was 7. 244 mg/L for 2 hours and the 95% confidence interval was 5. 278-9. 954 mg/L. The Carassius auratus mortality was zero under the concentration of 1. 25 mg/L for 96 hours, and 100 % under the concentration of 20. 0 mg/L for 5 hours. LC50 of EGA to the Carassius auratus was 7. 080 mg/L for 5 hours and the 95% confidence interval was 5. 202 -9. 635 mg/L. Conclusion Toxicity of ECA to fish is lower than that of niclosamide. The EGA thus represents a promising plant-derived molluscicide which is worthy of further investigation.

关 键 词：血水草 生物碱 鱼类 急性毒性试验 

分 类 号：R383.24[医药卫生—医学寄生虫学]