习惯性流产夫妇染色体脆性位点的观察  

Analysis of Chromosome Fragile Sites in the Habitual Abortion Couples.

作　　者：李启运 张晓梅 王长花 罗小金 

机构地区：[1]深圳市老年医学研究所细胞遗传室 [2]深圳市人民医院妇产科

出　　处：《中国优生与遗传杂志》2003年第3期42-43,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的　探讨习惯性流产夫妇细胞细胞遗传学病因。方法　采用低叶酸TC199培养诱导法 ,观察了 31对染色体核型无异常的习惯性流产夫妇染色体脆性位点 ,并观察了脆性位点的分布。结果　实验组染色体脆性位点的频率为 11.98% ;对照组为 4 .95 % ,两组相比差异非常显著。染色体脆性位点的的分布两组基本一致。结论　习惯性流产与染色体脆性位点频率增高有关与脆性位点分布关系不大。Objective: To investigate cytogenetic mechanism for habitual abortion. Methods: TC199 low level of folic acid cultivation method was performed to analyse both the frequency and the distribution of chromosome fragile sites in 31 habitual abortion couples. Results The frequency of the fragile sites in the habitual abortion couples is 11.98%, whereas that in the control group is 4.32%. The Fragile expression rate of two groups is significantly distinct from each other (P<0.05). But the distribution of chromosome fragile site proved to be coincident in both groups. Conclusions The habitual abortion is correlative with the higher expression rate of chromosome fragile sites, but seems independent of the distribution of Fras.

关 键 词：脆性位点 习惯性流产 染色体 

分 类 号：R714.21[医药卫生—妇产科学]