窒息新生儿尿中内皮素(ET-1)的变化与肾损伤的关系  

The level and it's significance of ET-1 of urinary in neonates with asphyxia.

作　　者：张本金[1] 董文斌[2] 唐章华[2] 王胜会[2] 胡晓[2] 陈书琴[2] 

机构地区：[1]四川达州市中心医院儿科,635000 [2]四川泸州医学院附属医院儿科

出　　处：《中国优生与遗传杂志》2003年第3期73-73,79,共2页Chinese Journal of Birth Health & Heredity

基　　金：四川省卫生厅科研基金资助 (编号 :9810 17)

摘　　要：目的　探讨窒息新生儿尿中ET - 1的变化与肾损伤的关系。方法　采用放射免疫分析检测窒息患儿尿中ET- 1水平 ,并同时测定尿中反应肾损伤的指标—β2微球蛋白 (MG)的水平。结果　轻度窒息组与正常组及重度窒息组与轻度窒息组比较 ,ET - 1、β2 -MG水平显著升高 (P <0 0 5 ) ,且ET - 1与β2 -MG之间呈显著正相关关系 (r =0 .72 ,P <0 .0 5 )。结论　尿中ET - 1水平的测定可作为判断新生儿窒息程度及肾损伤的一个重要指标。Objective: To explore the relationship between ET-1 of urinary and postasphyxial renal injury in neonatal asphyxia. Methosds: The level of ET-1 and β 2-MG in urinary were detected in neonates with asphyxia. Results: Compared with control, the level of ET-1 and β 2-MG were obviously increased in mild asphyxia group. In severe asphyxia group, the parameters above all were significantly increased compared with mild asphyxia group. and there were positive relationship between ET-1 and β 2-MG in all neonates with asphyxia. Conclusion: The level of ET-1 in urinary may be regarded as an indicator in evalulating the severity of asphyxia and postasphyxial renal injury in neonates.

关 键 词：新生儿窒息 肾损伤 ET-1 Β2微球蛋白 

分 类 号：R722.12[医药卫生—儿科]