盐酸氨溴索渗透泵控释片的体外释放度考察  

The in vitro release rate of ambroxol HCl osmotic pump controlled release tablets

作　　者：潘卫三[1] 常明[1] 刘宏飞[1] 武玉洁[1] 马静 

机构地区：[1]沈阳药科大学药学院药剂教研室,沈阳110016 [2]河北省石家庄市以岭药业,石家庄050091

出　　处：《中国新药杂志》2003年第7期543-545,共3页Chinese Journal of New Drugs

摘　　要：目的 :研究盐酸氨溴索渗透泵控释片的体外释放度。方法 :考察渗透泵在不同介质中的释放情况。结果 :渗透泵的释药不随释药环境的改变而改变。结论 :盐酸氨溴索渗透泵控释片释药稳定 ,零级释药明显 ,具备优良控释制剂的特征。Objective:To study the in vitro release rate of ambroxol HCl osmotic pump controlled release tablets.Methods:The release rate of ambroxol HCl osmotic pump controlled release tablets in various mediums was observed.Results:Drug release rate of the tablets did not change with the change of medium.Conclusions:The ambroxol HCl osmotic pump controlled release tablets have a stable release curve and conform to zero release order.

关 键 词：盐酸氨溴索 渗透泵控释片 体外释放 

分 类 号：R943[医药卫生—药剂学] R974.1[医药卫生—药学]