利钾尿肽与心钠素摩尔比在心房纤颤时的作用  

Role of kaliuretic peptide and molar ratio of kaliuretic peptide/ atrial natriuretic peptide in atrial fibrillation

作　　者：计达[1] 曾强[1] 沈洪[1] 范英鲜[1] 陈威[1] 宋杨丽[1] 

机构地区：[1]解放军总医院急诊科,北京100853

出　　处：《中国危重病急救医学》2003年第8期459-461,共3页Chinese Critical Care Medicine

基　　金：国家自然科学基金资助项目 ( 3 9970 80 6) ;军队"九五"医药卫生科研基金资助项目 ( 98Q0 92 )

摘　　要：目的 :探讨利钾尿肽 (KP)及 KP与心钠素 (ANP)摩尔比在心房纤颤 (房颤 )时的意义。方法 :用放射免疫 (放免 )分析法测定 2 3例阵发房颤患者和 2 4例持续房颤患者血浆中 KP与 ANP的水平 ,并以正常人作为对照。结果 :房颤患者血浆中 KP与 ANP的水平明显高于对照组 (P均 <0 .0 1) ,阵发房颤患者血浆中 KP/ ANP摩尔比显著低于正常对照组 (P<0 .0 1) ;持续房颤患者血浆中 KP/ ANP摩尔比与正常对照组相似 (P>0 .0 5 )。结论 :KP含量与Objective: To investigate the role of kaliuretic peptide(KP) and molar ratio of KP/ atrial natriuretic peptide(ANP) in atrial fibrillation. Methods: The levels of plasma KP and ANP in 23 patients with paroxysmal atrial fibrillation (groupⅠ), 24 patients with persistent atrial fibrillation (>1 year, groupⅡ) and 20 healthy humans(groupⅢ) were determined with radioimmunoassay. Results: Compared with groupⅢ, the levels of plasma KP and ANP of the groupⅠ and groupⅡ were both higher (both P <0 01). Compared with groupⅢ, the level of KP/ANP of the groupⅠ was lower ( P <0 01), while that of groupⅡ was no substantial change ( P >0 05). Conclusion: The change of levels in ANP, KP and ANP/KP may play important role in atrial fibrillation.

关 键 词：心房纤颤 利钾尿肽 心钠素 摩尔比 

分 类 号：R541.75[医药卫生—心血管疾病] R363.27[医药卫生—内科学]