SOS/Umu原位法测试生产环境空气中有害物质遗传毒性的研究  

APPLICATION OF SOS/UMU-TEST FOR STUDY ON GENETOXICITY OF AIR POLLUTANTS IN PRODUCTIVE ENVIRONMENT

作　　者：高锦伍[1] 尹建强[1] 吴晓文[1] 浦跃朴[2] 尹立红[2] 张徐军[2] 

机构地区：[1]南京铁道医学院预防医学系劳动卫生教研室 [2]南京铁道医学院预防医学系环境卫生教研室

出　　处：《南京铁道医学院学报》1992年第3期152-155,共4页Journal of Nanjing Railway Medical College

摘　　要：采用SOS/Umu原位法测试生产环境空气中混合性有害物质的联合遗传毒性。在现场电焊、熔铅及脱漆作业车间空气混合性污染物测试应用中,获得阳性结果,且测试样品剂量与β-半乳糖苷酶诱导活性(Iu 值)、诱导率(R 值)呈显著剂量—反应关系。结果表明,上述作业车间空气中的混合有害物质对细胞 DNA 有损伤作用,能引起遗传毒性作用。The SOS/Umu-test was used for detection of conoined genetox(?)city of mixed air pollutanants in productive cnvironment,Using this test,we obtaind positive results and found a sig(?)ricant dose-response relationship between dose and β-galactosidase activity or induction ratio in welding,melting lead and removing paint workshops. It is shown that mixed air pollutants in the workshops are capable of damaging DNA and inducins SOS (?)unction.

关 键 词：空气污染物 生产环境 遗传毒性 

分 类 号：R134.4[医药卫生—劳动卫生]