平喘药对PMN超氧阴离子释放的影响  

Effect of Antiasthmatic Drugs on Human PMNs Superoxide Production

作　　者：殷凯生[1] 古井秀彦 高木健三[2] 铃木隆二郎 佐竹辰夫 

机构地区：[1]南京医学院第一附属医院呼吸科 [2]日本国立名古屋大学医学部二内科

出　　处：《南京医学院学报》1992年第1期5-8,共4页

摘　　要：作者应用细胞色素C还原法,研究了数种平喘药对经FMLP活化的人中性粒细胞(PMN_s)超氧阴离子释放过程的影响。结果显示:异丙肾上腺素、Colforsin和Azelastine对PMN_s释放O_2^-过程具有显著的抑制作用,双丁酰环腺苷酸仅具轻度抑制作用,而AM-682对此过程几无抑制作用。并对上述作用机理和临床意义作了讨论。The effects ot an:ia.sthmatic drugs on respiration burst in activated human polymorphonuclear neutrophils (PMNs) with method of cytochrome C reduction were investigated. The results showed that isoprotereno], colforsin and azelastine indueed a dose-dependent inhibition of FMLP-caused superoxied production by human PMN_s. D butyryl cyclic AMP only had a mild inhibitory effect and AM-682 had no effect on human PMNs superoxide production. The mechanism of the effect and its significance in therapy of asthma are discussed.

关 键 词：平喘药 中性粒细胞 超氧阴离子 

分 类 号：R963[医药卫生—微生物与生化药学]