白三烯拮抗剂ONO-1078的一般神经药理特点  

Neuropharmacological properties of ONO-1078,a leukotriene antagonist in mice

作　　者：胡全[1] 魏尔清[1] 章征[1] 朱朝阳[1] 

机构地区：[1]浙江大学医学院药理学教研室

出　　处：《中国现代应用药学》2003年第4期259-262,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金项目 (No .3 9770 2 70 )

摘　　要：目的　观察白三烯拮抗剂ONO 10 78对小鼠的一般神经药理作用 ,评价其对中枢的安全性。方法　测定自发活动、运动及协调能力试验、水迷宫试验、跳台实验以及镇痛试验等 ,研究ONO 10 78( 0 .2 ,1.0 ,5 .0mg·kg-1,ip)对小鼠神经活动的影响。结果　大剂量ONO 10 78( 5 .0mg·kg-1)对小鼠自发活动有抑制作用 ,但是未观察到其它明显的神经作用。结论　ONO 10 78对中枢神经系统作用轻微 。OBJECTIVE ONO 1078, a leukotriene antagonist, has neuroprotective effect on brain ischemia. This study aims to determine the effects of ONO 1078 on central nervous system to evaluate its safety in mice. METHOD Spontaneous locomotor test, neuromuscular and vestibulomotor functions, water maze test, step down test and analgesic tests were used to observe the central effects of ONO 1078 (0.2, 1.0, 5.0 mg·kg -1 , ip) in mice.RESULTS ONO 1078 had suppressive effect on spontaneous locomotor activity in a larger dose (5.0 mg·kg -1 ), but no other significant central effects were observed in mice.CONCLUSION ONO 1078 has a lower toxicity on central nervous system and may be safe for the use in the treatment of brain ischemia.

关 键 词：ONO-1078 自发活动 行为学作用 学习记忆 镇痛 白三烯拮抗剂 

分 类 号：R971[医药卫生—药品] R964[医药卫生—药学]