亚低温联合钙拮抗剂治疗丘脑下部伤的临床研究  

Study of the clinical effect of mild hypothermia and calcium antagonist on patients with hypothalamus injury

作　　者：杨少春[1] 王文浩[1] 林国文[1] 罗飞[1] 陈文彬[1] 

机构地区：[1]中国人民解放军第175医院神经外科,363000

出　　处：《福建医药杂志》2003年第4期8-10,共3页Fujian Medical Journal

摘　　要：目的　探讨亚低温及 Ca2 +拮抗剂对丘脑下部伤的治疗作用。方法　 4 6例病人 ,分为亚低温联合 Ca2 +拮抗剂治疗组和对照组。治疗组 2 0例 ,均于伤后 2 4小时内行亚低温及 Ca2 + 拮抗剂治疗 ,肛温控制在 30～ 33℃ ,持续 3～ 10天 ,伤后同时给予尼莫同静滴。对照组肛温控制在 36 .5～ 37℃ ,其它治疗同亚低温组。两组均监测病人的生命体征、血糖、血气、血电解质。两组病人均于伤后 3个月时根据 GOS评估法判定疗效。结果　与对照组比较 ,治疗组伤后早期的高血糖显著下降 ,血气及血电解质无显著差异 ;无严重并发症 ;死亡率降低 ,恢复良好率提高 ,预后显著改善。结论　亚低温联合 Ca2 + 拮抗剂治疗丘脑下部伤安全有效 ,可降低死亡率 ,提高生存质量 。Objective\ To study the clinical effect of mild hypothermia and calcium antagonist on patients with hypothalamus injury.Methods\ All 46 patients with hypothalamus injury(Glasgow Coma Scale Score of 8 or less on admission)were divided into the group of hypothermia and calcium antagonist therapy(20 cases)and the control group(26 cases).Hypothermia and calcium antagonist(Nimotop)were induced within 24 hours of injury.Rewarming was begun on 3～10 days after the rectal temperature reached 30～33℃.Meantime,the vital sign,blood sugar,blood gas valus,blood electrolytes were measured.The rectal temperature of control patients was induced to 36 5～37℃.According to Glasgow Outcome Scale(GOS),the prognosis of the patients was evaluated.Results\ In comparison with the control group,during mild hypothermia hyperglycemia improved dominantly( P <0 05).The vital sign,blood gas valus and blood electrolytes did not significantly change.The decreased mortality and good recovery were also found in hypothermia group.Conclusions\ Mild hypothermia and calcium antagonist are safe and effective for patients with hypothalamus injury,which can reduce the mortality and improved the prognosis.

关 键 词：丘脑下部伤 亚低温 钙拮抗剂 治疗 临床研究 预后 

分 类 号：R651.15[医药卫生—外科学]