^(13)C-美沙西汀的含量测定法研究  

Quantitative determination of ^(13)C-methacitin stable isotopes in nuclear medicine

作　　者：张金榜[1] 贾忠 吕东煜[1] 陈大安[3] 张晓雪[4] 

机构地区：[1]兰州医学院医学工程系,730000 [2]兰州市肺科医院药械科 [3]兰州医学院附属一院 [4]甘肃省人民医院

出　　处：《兰州医学院学报》2003年第3期5-6,共2页Journal of Lanzhou Medical College

摘　　要：目的　研究了诊断用药1 3C -美沙西汀的含量的测定方法 ,建立一种简单的药物含量分析方法 ,指导临床准确用药。方法　先用重氮化滴定法测出1 3C—美西沙汀和主要杂质对 -乙酰胺基酚的总含量 ,再用比色法测出对 -乙酰胺基酚的含量 ,从总量中扣除后者即得1 3C -美西沙汀含量。结果　测得数据与出厂含量基本吻合 ,证明其测定数据准确可靠。结论　该测定方法操作简便 ,是诊断用药1 3C -美沙西汀的含量测定的一种较理想方法。Objective The determination method of 13C-methacitin which is diagnose drug was studied to establish a convenient procedune of analysis content of 13C-Methacitin . Methods The method and procedure to determine 13C-Methacitin which is a diagnose drug in 13C breath test was given by titration and spectrophotometry.Results The experiment results showed that the method is accurate and convenient.Conclusion The method is easy to operat. And also it is method of ideal to determination of 13C-Methacitin.

关 键 词：13C-美沙西汀 诊断用药 含量测定 重氮化滴定法 对-乙酰胺基酚 

分 类 号：R981[医药卫生—药品] R927.2[医药卫生—药学]