新型的二氢吡啶类钙通道阻滞药乐卡地平的抗高血压作用  

Antihypertension effect of lercanidipine——a new type dihydropyridine calcium antagonist

作　　者：罗永鑫[1] 贡沁燕[1] 

机构地区：[1]复旦大学上海医学院药理学系,上海200032

出　　处：《中国新药与临床杂志》2003年第9期561-566,共6页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：乐卡地平是一种新型的二氢吡啶类钙通道阻滞药 ,其亲脂性强 ,对血管平滑肌的舒张作用缓慢、持久、显著 ;动物及临床实验显示其降压作用持久、安全 。Lercanidipine is a novel dihydropyridine calcium channel blocker.It is a highly lipophilic drug and has a slow onset and longer duration of action. Preclinical and clinical evidences have shown that its anti hypertension effect is durable and safe. It may also protect end organ damages.

关 键 词：高血压 二氢吡啶类钙通道阻滞药 乐卡地平 理化性质 药物代谢动力学 药理作用 

分 类 号：R972.4[医药卫生—药品] R544.1[医药卫生—药学]