苦参碱缓释片的研制及体外释放特性研究  

Preparation of Matrine Sustained-release Tablet and Study on Characteristics of the Release Trial in Vitro

作　　者：李晏[1] 吴学孔[2] 杨延莉 邹豪[3] 蒋雪涛[3] 

机构地区：[1]中国人民解放军第411医院药剂科,上海200081 [2]中国人民解放军海军卫生部,北京100841 [3]中国人民解放军第二军医大学药学院药剂教研室,上海200433

出　　处：《解放军药学学报》2003年第4期274-277,共4页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的　为延长苦参碱的作用时间 ,将其制成缓释片 ,并对该缓释片的体外释放特性进行研究。方法　利用亲水性凝胶骨架将苦参碱制成缓释片 ,并进行体外累积释放度测定。结果　该缓释片的释药曲线基本符合Higuchi方程 ,具有缓释片的体外溶出特征。硬度和溶出介质的pH对释药行为影响不大 ,而转速及辅料用量有一定影响。结论　苦参碱缓释片释药缓慢、平稳 ,达到了设计要求 ,有利于降低不良反应发生率。Aim To prepare matrine sustained-release tablet for prolong effective time and study on characteristics of the release trial in vitro.Methods Matrine was used as a water soluble drug model to prepare sustained-release matrix tablets and the release rate of sustained-release tablet was determined by UV method in vitro.Results The dissolution profiles of matrine sustained-release tablet conformed to Higuchi formula basically.The release rate depended on the dissolution basket rotation and the content of excipient.The result showed release rate was not affected by pH of dissolution medium and rigidity of tablet.Conclusion The study of matrine sustained-release tablet achieved the goal of design.This sustained-release tablet is helpful to decrease the ratio of adverse reactions.

关 键 词：苦参碱缓释片 体外释放特性 制备 影响因素 

分 类 号：R286.0[医药卫生—中药学]