280枚人类细胞期胚胎冷冻、复苏及移植结果分析  

Analysis of 280 frozen-thawed human embryos and embryos transplant results

作　　者：韩晓敏[1] 李慧林[1] 

机构地区：[1]泰安市中心医院,山东泰安271000

出　　处：《山东医药》2003年第24期13-14,共2页Shandong Medical Journal

摘　　要：目的　探讨人类 4～ 6细胞期胚胎冷冻、复苏及移植后的妊娠情况。方法　对人类 4～ 6细胞期胚胎进行慢速冷冻、快速复苏 ,比较冷冻前后优质胚胎率及移植后的妊娠情况。结果　 5 8例患者共 2 80枚胚胎实施冷冻并复苏。冷冻前后平均优质胚胎率分别为 5 9.2 %(16 6 / 2 80 )与 40 .3%(113/ 2 80 ) ,两者相比差异有显著性 (P <0 .0 5 )。冻胚复苏移植后临床妊娠率为 37.9%(2 2 / 5 8) ,与同期新鲜胚胎移植临床妊娠率 41.5 %(42 / 10 1)相比差异无显著性 (P >0 .0 5 )。患者累积临床妊娠率为 5 6 .6 %(5 7/ 10 1)。结论　冷冻、复苏可降低优质胚胎率 ,但有较满意的临床妊娠率。Objective To analysis frozen-thawed 4~6cells human embryos and clinical pregnancy after embryo transplant.Methods A Slow-freeing and rapid-thawing protocol were used in 4~6 cells human embryos,comparing good quality embryo rates and clinical pregnancy after embryo transplant.Results 280 4~6 cells embryos of 58 patients were frozen and thawed.The average good quality embryo rate of pre-freeing and post-thawing were 59.2%(166/280)and 40.3%(113/280)respectively.There was significant difference between two groups (P<0.05).The clinical pregnant rate of human embryo in the freeing-thawing group (37.9%) was similar to that in fresh embryo transfer group(41.5%),P>0.05.The cumulative clinical pregnant rate of patients was 56.6%(57/101).Conclusion There are lower good quality embryo rate of frozen-thawed embryos but good clinical pregnancy.

关 键 词：细胞期 胚胎冷冻 胚胎复苏 胚胎移植 结果分析 临床妊娠率 

分 类 号：R711.6[医药卫生—妇产科学] R392-33[医药卫生—临床医学]