高纯度天然右旋龙脑的制备研究  

STUDY ON PREPARATION OF HIGH-PURITY NATURAL d-BORNEOL

作　　者：宋永芳[1] 罗嘉梁[1] 

机构地区：[1]中国林业科学研究院林产化学工业研究所,江苏南京210042

出　　处：《林产化学与工业》2003年第3期11-14,共4页Chemistry and Industry of Forest Products

基　　金：原林业部1996年重点项目(96 10)

摘　　要：　以樟树[Cinnamomumglanduliferum(Wall)Nees]枝叶为原料经水蒸气蒸馏、升华得到70%～80%粗d 龙脑。为制备高纯度天然d 龙脑,进行了不同溶剂、不同溶剂量、结晶次数和结晶时间对d 龙脑纯度影响的研究。并用GC、GC/MS分析鉴定所制备的天然d 龙脑,用扫描电子显微镜观察d 龙脑结晶过程中晶体的结构变化。结果表明,汽油是结晶d 龙脑最好的溶剂,当物料比为1∶1.7～2.0、结晶时间4d以上时,天然d 龙脑的纯度可达99%以上。精制天然d 龙脑产品的分析数据为:外观白色片状结晶,右旋龙脑含量>99%,旋光度[α]20D>+37°,熔点205～209℃,重金属<5×10-6,砷(As)<2×10-6。Crude dborneol was obtained by water vapor distillation and sublimation from leaves of Cinnamomum glanduliferum(Wall) Nees.In order to prepare highpurity dborneol,experiments were carried out to investigate the effects of different solvent,solvent amount, times of crystallization and crystallizing time.Highpurity dborneol was analyzed by GC and GC/MS,and crystal of dborneol was examined by scanning electron microscopy(SEM).Results showed that gasoline is the best solvent for crystallizing dborneol,purity of dborneol product was over 99% using material:solvent ratio 1∶1.7-2.0,and crystallizing time 4 days.Analytical data of the fine natural dborneol products are:appearance of white slice crystals,dborneol content>99%,optical rotation \20d>+37,melting point 205-209 ℃,heavy metals content <5 millionth and arsenide(As) content<2 millionth.

关 键 词：天然右旋龙脑 制备 樟树 d-龙脑 纯度 电子显微镜扫描 中草药 

分 类 号：TQ461[化学工程—制药化工]