西尼地平核磁共振碳谱氢谱的谱峰归属  

Identification for the Hydrogen and Carbon Spectra of Cilnidipine by Nuclear Magnetic Resonance

作　　者：张家海[1] 杜定准[2] 吴季辉[1] 

机构地区：[1]中国科技大学生命科学院,中国科学院结构生物学重点实验室,合肥230026 [2]中国科技大学化学与材料科学学院,合肥230026

出　　处：《分析化学》2003年第9期1044-1047,共4页Chinese Journal of Analytical Chemistry

基　　金：国家 973资助项目 (No .G19990 75 60 5 )

摘　　要：利用普通1 H NMR ,1 3C NMR ,极化转移谱 (DEPT)以及同核相关谱 (COSY)、异核相关谱 (HSQC) ,特别是远程偶合谱 (HMBC)等多种核磁研究方法对新型的血管扩张药西尼地平的1 H、1 3C信号进行完全归属。对由于分子结构对称而引起的化学位移相差最小为 0 .94Hz的两个碳加以区分 。The structure of the title compound was identified by H-1, C-13, DEPT (distortionless enhancement by polarization transfer) and various two dimensional nuclear magnetic resonance spectroscopy, such as COSY (correlation spectroscopy), HSQC (heteronuclear correlation spectroscopy) and HMBC (heteronuclear multiple bond correlation spectroscopy). All the chemical shifts of H-1 and C-13 were assigned. The high efficiency of the HMBC in the structure research, of complex and high symmetric compounds was discussed.

关 键 词：西尼地平 核磁共振 碳谱 氢谱 谱峰 近似对称性 同核相关 异核相关 远程偶合 药理作用 抗动脉粥样硬化 

分 类 号：O657.2[理学—分析化学]