三唑仑苯二氮燐类药物的电喷雾质谱裂解特征  

Fragmentation Behaviors of Triazolobenzodiazepines by Electrospray Ionization/Quadrupole Time-of-Flight Mass Spectrometry

作　　者：李馨[1] 王英武[1] 顾景凯[1] 钟大放[1] 王玲[2] 陈刚[2] 

机构地区：[1]吉林大学药物代谢研究中心,生命科学学院,长春130021 [2]吉林大学分析测试中心,长春130021

出　　处：《分析化学》2003年第9期1105-1108,共4页Chinese Journal of Analytical Chemistry

摘　　要：采用电喷雾 四极杆飞行时间质谱 (ESI QqTOF)联用技术 ,对 3种三唑仑苯二氮类药物进行CID研究 ,并以质子化准分子离子 [M +H]+ 作为内标物 ,对碎片离子进行了准确质量测定 ,确认了这些碎片离子的元素组成 ,探讨了该类化合物的质谱裂解规律。研究发现 ,它们的ESI MS2 (源内 )和ESI MS3质谱分别生成脱去N2 分子、HCN或CH3CN分子和Cl原子的碎片离子 ,其中m z 2 0 5为 3种药物共有的碎片离子 。To investigate fragmentation behaviors of triazolobenzodiazepines, the collision induced dissociation (CID) of electrospray ionization/quadrupole time-of-flight mass spectrometry (ESI-QqTOF) was applied to three triazolobenzodiazepines. Using the protonated pseudo-molecular ions + as internal reference compounds, the accurate mass and elemental composition of the fragment ions were determined. The MS 2 in source and MS 3 spectra of each compound gave characteristic fragmentations of +, + and [M+H-HCN or CH 3CN] +, and the common ion of m/z 205 was also found. These characteristics can be used for future structure elucidation in the studies on metabolism and quantitation of triazolobenzodiazepines in human.

关 键 词：三唑仑苯二氮Chuo类药物 电喷雾质谱 裂解特征 四极杆飞行时间质谱 镇静催眠药物 定量分析 

分 类 号：O657.63[理学—分析化学]