红斑狼疮样雄性BXSB小鼠模型肾脏受累状况的研究  

Study of Pathological Severity in Lupus-prone BXSB Mice

作　　者：周素荣[1] 徐世正[1] 刘传玉[1] 周心房[1] 熊腊元[1] 

机构地区：[1]武汉大学人民医院皮肤科,武汉430060

出　　处：《武汉大学学报（医学版）》2003年第4期347-349,共3页Medical Journal of Wuhan University

摘　　要：目的 :探讨系统性红斑狼疮样动物模型雄性BXSB小鼠肾脏病变进展状况。方法 :分别测定不同月份的BXSB小鼠的 2 4h尿蛋白含量及其肾脏免疫复合物沉积状况。结果 :雄性BXSB小鼠 2月龄出现肾脏病理改变 ,3月龄出现临床指标改变。结论 :雄性BXSB小鼠 2月龄出现肾脏病理改变 ,3月龄肾脏出现临床指标改变 。Objective: To observe the status of the nephritis of lupus prone BXSB mice. Methods: the content of 24 hour urine protein and the deposition status of immune complex in nephritis of lupus prone BXSB mice with age varying from 1～6 month were observed in our experiment. Results: Pathological changes of kidney was found in 2 month male mice,and alteration of clinical marker was found in 3 month male mice. The content of 24 hour urine protein and the deposition status of immune complex in nephritis changed according to the age. Conclusion: The BXSB male mice of third month may suffered from lupus nephritis.

关 键 词：红斑狼疮样雄性BXSB小鼠模型 肾脏受累状况 研究 系统性红斑狼疮 抗原抗体复合物 

分 类 号：R593.24[医药卫生—内科学]