L-精氨酸对慢性低氧大鼠肺动脉压力及管壁胶原的影响  

Effect of L-Arg on Pulmonary Arterial Pressure and Pulmonary Arterial Wall Collagen in Chronic Hypoxic Rats

作　　者：张常娥[1] 李佳[1] 陈红霞[1] 曹霞[1] 赵小玉[1] 

机构地区：[1]咸宁学院医学院病理生理学教研室,湖北咸宁437100

出　　处：《咸宁学院学报（医学版）》2003年第3期164-166,共3页Journal of Xianning Univarsity(medical Sciences)

摘　　要：目的探讨L 精氨酸对慢性低氧大鼠肺动脉压力及管壁胶原的影响。方法 2 4只Wistar大鼠随机分为对照组 (C)、低氧组 (H1)和低氧 +L 精氨酸组 (H2 ) ,常压低氧时间 4周 ,采用免疫组化法和图像分析检测肺动脉管壁I、Ⅲ型胶原光密度的变化 ,并测定大鼠平均肺动脉压 (mPAP)。结果H1组mPAP显著高于C组和H2 组 (P <0 .0 1 ) ;H1组肺小动脉I型胶原平均光密度值较C组和H2 组高 (P <0 .0 1 ) ,Ⅲ型胶原平均吸光度值各组间差异无显著性 (P >0 .0 5 ) ,结论LObjective To study the effect of L-Arg on pulmonary arterial pressure and pulmonary arterial wall collagen in rats with chronic hypoxia.Methods Twenty-four rats were randomly divided into three groups(n=8):control group(C),hypoxia group(H1),and hypoxia+L-Arg group(H2).The rats were all accepted hypoxia-handling for 4 weeks,the mean pulmonary arterial pressure (mPAP) was measured,the optical density (OD) changes of arterial wall collagen I and Ⅲ were detected by immunohistochemistry and image analyzer.Results The mPAP in group H1 were significantly higher than that of group C and H 2(P<0.01),the OD of collagen I in group H 1 were significantly higher than that of group C and H 2 (P<0.01),but there were not significant difference of OD of collagen Ⅲ among the three groups (P>0.05).Conclusion L-Arg can prevent the formation of pulmonary hypertension and the collagen deposition in arterial wall in chronic hypoxic rats.

关 键 词：L—精氨酸 慢性低氧大鼠 肺动脉压力 管壁胶原 影响 肺动脉高压 

分 类 号：R543.2[医药卫生—心血管疾病]