慢性捆绑应激致大鼠海马CA_3区锥体细胞超微结构的变化  

The Ultrastructural Change of the Pyramidal Cells in the Hippocampus CA3 Area of Rats Caused by Chronic Restraint Stress

作　　者：廖敏[1] 刘能保[2] 李宏莲[2] 张敏海[2] 杨世民[2] 

机构地区：[1]咸宁学院医学院组织胚胎学教研室,湖北咸宁437100 [2]华中科技大学同济医学院组织胚胎学教研室

出　　处：《咸宁学院学报（医学版）》2003年第3期161-163,共3页Journal of Xianning Univarsity(medical Sciences)

摘　　要：目的观察慢性捆绑应激紧张对大鼠海马神经元超微结构的影响。方法实验组采用捆绑器每天捆绑 6h ,2 1d后用透射电镜观察海马CA3区锥体细胞超微结构的变化。结果实验组海马CA3区锥体细胞细胞器减少 ,粗面内质网局部扩张并脱颗粒 ;线粒体肿胀 ,嵴数量减少 ;脂褐素增加 ;核膜内陷 ,核内外有空泡。Objective To observe the effects of chronic restraint stress on ultrastructure of neuron in the hippocampus of rats.Methods The experimental rats were restrained for 6 hours every day.After 21days,the ultrastructural changes of the pyramidal cells in rats'hippocampus CA 3 area were observed with transmission electromicroscopy.Results The organellae of the pyramidal cells in hippocampus CA3 area of the experimental rats decreased.The mitochondria swelled and the number of their crista decreased.The lipofuscin increased in cytoplasm.The nucleus membrane sank inside, and vacuolation degeneration was found in the nucleus and cytoplasm.Conclusion chronic restraint stress leads to the degeneration of hippocampus pyramidal cells.

关 键 词：慢性捆绑应激 大鼠 海马 CA3区锥体细胞 超微结构 

分 类 号：R329.27[医药卫生—人体解剖和组织胚胎学]