冠心病患者细胞粘附分子的水平变化和临床意义  

The Change and Clinical Significance of Adhesion Molecules in Periheral Blood with Coronary Heart Disease Patients

作　　者：潘晓娟[1] 毛咏秋[2] 李迪[1] 

机构地区：[1]成都市第九人民医院,四川成都610015 [2]四川大学华西医院肿瘤防治中心,四川成都610041

出　　处：《华西医学》2003年第3期334-335,共2页West China Medical Journal

摘　　要：目的 :探讨冠心病患者外周血白细胞粘附分子 β2 整合素 (β2 -intergrin ,CD18)和血清可溶性细胞间粘附分子 - 1(solubleintercellularadhesionmolecule - 1,sICAM - 1,CD5 4 )、血管细胞粘附分子 - 1(solublevascularcelladhesionmolecule - 1,sVCAM - 1,CD10 6 )变化及其意义。方法 :采用流式细胞仪技术检测 4 5例冠心病患者外周血白细胞CD18以及血清sICAM - 1和sVCAM - 1的表达。结果 :冠心病患者外周血白细胞CD18以及血清sICAM- 1和sVCAM - 1表达显著增加。结论 :冠心病患者外周血白细胞CD18以及血清sICAM - 1和sVCAM - 1的水平对冠心病的早期诊断具有一定的临床意义。Objective:To clarify the change and significance of adhesion molecules in periheral blood with coronary heart disease patients.Method:The expression of β 2-intergrin(CD18)on neutropnils,Serum soluble intercellular adhesion molecule-1(sICAM-1)and soluble vascular cell adhesion molecule-1(sVCAM-1)level were determined by using flow cytometry in 45 cases of coronary heart disease and 28 cases of normal subjects as controls.Result:The mean fluorescence intensity of CD18,sICAM-1 and sVCAM-1 were significantly higher in coronary heart disease patients than in the controls( P <0 05).Conclusions:Serum sICAM-1 and sVCAM-1 levels and the CD18 expression on neutrophils were claimed to be valuable markers in the early diagnosis of coronary heart disease.

关 键 词：冠心病 细胞粘附分子 Β2整合素 血管细胞粘附分-1 

分 类 号：R541.4[医药卫生—心血管疾病]