青霉素Ⅴ治疗游走性红斑2周或3周的疗效比较及回顾  

Comparison of a two- or three- week regimen and a review of treatment of erythema migrans with phenoxymethylpenicillin

作　　者：Aberer E. Kahofer P. Binder B. 罗素菊 徐波 

机构地区：[1]Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, AT- 8036 Graz, Austria,Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第4期48-49,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: A longer duration treatment is preferred in erythema migrans (EM) to prevent late complaints. Objectives: To determine whether 20 (20d- pt) or 14 days (14d- pt) of phenoxymethylpenicillin (PenV) have similar efficacy in treating EM and preventing further sequelae. Patients and Methods: In a prospective double- centre study, 102 patients with EM were treated with PenV 1.5 million IU thrice daily for either 20 or 14 days and followed up for 12 months. Results: The primary cure rate after treatment with PenV was 91.5% (79.6- 97.6) for 20d- pt vs. 91.7% (77.5- 98.2) for 14d- pt; p >0.99). In 7 patients (420d- pt and 314d- pt), persistent or newly arising symptoms required retreatment. After 1 year, all patients were cured. The immune response showed no statistical difference between the treatment groups in the follow- up period. Conclusion: A 2- week treatment regimen of PenV seems to be as effective as a 3- week course with no statistical differences for clinical and serological findings after treatment.Background: A longer duration treatment is preferred in erythema migrans (EM) to prevent late complaints. Objectives: To determine whether 20 (20d- pt) or 14 days (14d- pt) of phenoxymethylpenicillin (PenV) have similar efficacy in treating EM and preventing further sequelae. Patients and Methods: In a prospective double- centre study, 102 patients with EM were treated with PenV 1.5 million IU thrice daily for either 20 or 14 days and followed up for 12 months. Results: The primary cure rate after treatment with PenV was 91.5% (79.6- 97.6) for 20d- pt vs. 91.7% (77.5- 98.2) for 14d- pt; p >0.99). In 7 patients (420d- pt and 314d- pt), persistent or newly arising symptoms required retreatment. After 1 year, all patients were cured. The immune response showed no statistical difference between the treatment groups in the follow- up period. Conclusion: A 2- week treatment regimen of PenV seems to be as effective as a 3- week course with no statistical differences for clinical and serological findings after treatment.

关 键 词：游走性红斑 免疫反应 血清学 

分 类 号：R758.61[医药卫生—皮肤病学与性病学]