非那司提治疗女性脱发  

Finasteride treatment of female pattern hair loss

作　　者：Iorizzo M. Vincenzi C. Voudouris S. A. Tosti 王琼 

机构地区：[1]Department of Dermatology, University of Bologna, Via Massarenti, 1, 40138 Bologna, Italy Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第5期19-20,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Objective: To evaluate the efficacy of oral finasteride therapy associated with an oral contraceptive containing drospirenone and ethinyl estradiol in premenopausal women with female pattern hair loss. Setting: Outpatient consultation for hair disorders at the Department of Dermatology, University of Bologna. Patients and Intervention: Thirty-seven women with female pattern hair loss were treated with oral finasteride, 2.5 mg/d, while taking an oral contraceptive containing drospirenone and ethinyl estradiol. Treatment efficacy was evaluated using global photography and the hair density score from videodermoscopy. A self-administered questionnaire was used to assess patient evaluation of treatment effectiveness. Results: At 12-month follow-up, 23 of the 37 patients were rated as improved using global photography (12 were slightly improved, 8 were moderately improved, and 3were greatly improved). No improvement was recorded in 13 patients. One patient experiencedworsening of the condition. There was a statistically significant (P=.002) increase in the hair density score in 12 patients. No adverse reactions to the drug were reported. Conclusions: Sixty-two percent of the patients demonstrated some improvement of their hair loss with the use of finasteride, 2.5 mg/d, while taking the oral contraceptive. It is unclear whether the success was due to a higher dosage of finasteride (2.5 mg instead of 1 mg) or to its association with the oral contraceptive containing drospirenone, which has an antiandrogenic effect. Further studies are necessary to understand which patterns of female pattern hair loss respond better to this treatment.Objective: To evaluate the efficacy of oral finasteride therapy associated with an oral contraceptive containing drospirenone and ethinyl estradiol in premenopausal women with female pattern hair loss. Setting: Outpatient consultation for hair disorders at the Department of Dermatology, University of Bologna. Patients and Intervention: Thirty-seven women with female pattern hair loss were treated with oral finasteride, 2.5 mg/d, while taking an oral contraceptive containing drospirenone and ethinyl estradiol. Treatment efficacy was evaluated using global photography and the hair density score from videodermoscopy. A self-administered questionnaire was used to assess patient evaluation of treatment effectiveness. Results: At 12-month follow-up, 23 of the 37 patients were rated as improved using global photography (12 were slightly improved, 8 were moderately improved, and 3were greatly improved). No improvement was recorded in 13 patients. One patient experiencedworsening of the condition. There was a statistically significant (P=.002) increase in the hair density score in 12 patients. No adverse reactions to the drug were reported. Conclusions: Sixty-two percent of the patients demonstrated some improvement of their hair loss with the use of finasteride, 2.5 mg/d, while taking the oral contraceptive. It is unclear whether the success was due to a higher dosage of finasteride (2.5 mg instead of 1 mg) or to its association with the oral contraceptive containing drospirenone, which has an antiandrogenic effect. Further studies are necessary to understand which patterns of female pattern hair loss respond better to this treatment.

关 键 词：非那司提 毛发疾病 口服避孕药 屈螺酮 乙炔雌二醇 抗雄激素作用 BOLOGNA 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]