刮除术和光动力疗法治疗局灶性真皮发育不良(Goltz)综合征伴外生肉芽组织1例  

A case of focal dermal hypoplasia (Goltz) syndrome with exophytic granulation tissue treated by curettage and photodynamic therapy

作　　者：Mallipeddi R. Chaudhry S.I. Darley C.R. Kurwa H.A. 刘艳 

机构地区：[1]Dermatological Surgery and Laser Unit, St. John' s Institute of Dermatology, St. Thomas' Hospital, London, SE1 7EH, United Kingdom Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第5期28-28,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Focal dermal hypoplasia (Goltz) syndrome is a rare genetic disorder characterized by cutaneous, ectodermal and meso dermal defects. We present a case in which painful, exophytic granulation tissue has been the main symptom over the past 15 years. After unsatisfactory results with a number of treatment modalities including topical steroids, silver-nitrate applications, cryotherapy, curettage, excision and pulsed-dye laser, we achieved significant benefit with curettage in combination with photodynamic therapy. Although impaired wound healing has been described in focal dermal hypoplasia, this is, to our knowledge, the first time that pyogenic granuloma-like lesions have been reported.Focal dermal hypoplasia (Goltz) syndrome is a rare genetic disorder characterized by cutaneous, ectodermal and meso dermal defects. We present a case in which painful, exophytic granulation tissue has been the main symptom over the past 15 years. After unsatisfactory results with a number of treatment modalities including topical steroids, silver-nitrate applications, cryotherapy, curettage, excision and pulsed-dye laser, we achieved significant benefit with curettage in combination with photodynamic therapy. Although impaired wound healing has been described in focal dermal hypoplasia, this is, to our knowledge, the first time that pyogenic granuloma-like lesions have been reported.

关 键 词：Goltz 光动力疗法 刮除术 肉芽组织 化脓性肉芽肿 脉冲染料激光 疼痛性 局部激素 遗传性疾病 

分 类 号：R758.5[医药卫生—皮肤病学与性病学]