两种具有调节血管生成作用的氨基酰-tRNA合成酶  

Regulation of Angiogenic Signaling Pathway by Two Human Aminoacyl-tRNA Synthetases

作　　者：赵明炜[1] 王恩多[1] 

机构地区：[1]中国科学院上海生命科学研究院,生物化学与细胞生物学研究所,分子生物学国家重点实验室,上海200031

出　　处：《生物化学与生物物理进展》2003年第5期689-693,共5页Progress In Biochemistry and Biophysics

基　　金：中国科学院创新项目 (KSCX2 2 0 4) ;国家高技术"863"计划资助项目 ( 2 0 0 1AA2 3 5 0 71);上海市科学技术委员会资助项目( 0 2DJ14 0 5 67)~~

摘　　要：氨基酰 tRNA合成酶是生物体内蛋白质合成过程中的一类关键酶 ,它催化体内tRNA的氨基酰化反应 .作为一类古老的蛋白质 ,氨基酰 tRNA合成酶在其漫长的进化过程中 ,通过其他结构域的插入或融合逐渐演化出许多新的功能 .最近的研究结果表明 ,人酪氨酰 tRNA合成酶的片段具有促进血管生成的功能 ,而人色氨酰 tRNA合成酶的片段则具有抑制血管生长的功能 .在哺乳动物细胞中 ,蛋白质的生物合成途径与细胞信号转导途径紧密相连 .今后 ,随着对氨基酰 tRNA合成酶研究的不断深入 。Aminoacyl-tRNA synthetases are key enzymes in protein biosynthesis that catalyze aminoacylation of their cognate tRNA. During their long evolution, these ancient enzymes incorporated new domains by insertions or fusions to the class-defining catalytic core to attend more functions. Recently, fragments of the closely related human tyrosyl- and tryptophanyl-tRNA synthetases were discovered to be active in angiogenesis signaling pathway. One synthetase fragment has proangiogenic activity, while the other is antiangiogenic. These two tRNA synthetases link protein synthesis to a major cell-signaling pathway in the given mammalian cells. The results with animals suggest that therapeutic applications for many human diseases such as neovascular eye disease and tumor are possible with these tRNA synthetases.

关 键 词：氨基酰-TRNA合成酶 血管生成 细胞因子 信号转导 

分 类 号：Q55[生物学—生物化学] Q26