熔融聚合法直接合成生物降解材料PGLA50/50  

Direct synthesis of biodegradable material PGLA50/50 via melt polycondensation

作　　者：汪朝阳[1] 赵耀明[1] 王方[1] 王浚[1] 周玲[1] 王英[1] 

机构地区：[1]华南理工大学材料学院,广东广州510640

出　　处：《现代化工》2003年第8期25-27,29,共4页Modern Chemical Industry

基　　金：广东省自然科学基金资助项目 (0 2 0 885)

摘　　要：以等摩尔乙醇酸、L-乳酸为原料 ,通过熔融聚合法直接合成生物降解材料聚乙醇酸 -乳酸 (PGLA50 / 50 )。当在 1 65℃、70Pa下熔融聚合 1 0h ,以质量分数为 0 .5 %的氯化亚锡为催化剂时 ,产物特性黏数最高可达 0 .1 993dL/g。Starting from glycolic acid (GA) and L-lactic acid (L-LA) and n(GA):n(L-LA)=1:1, biodegradable material poly(glycolic acid-lactic acid) (PGLA50/50) was directly synthesized via the melt polycondensation. Catalyzed by 0.5% (weight percent) SnCl2, at 165°C and under 70 Pa, PGLA50/50 with the highest intrinsic viscosity of 0.1993 dL/g was produced after 10 h. The direct melt polycondensation for the synthesis of PGLA50/50 is simpler and more practicable, and the lower cost is beneficial to the more extensive application of PGLA50/50, especially in the drug delivery field.

关 键 词：聚乙醇酸-乳酸(PGLA) 直接熔融聚合 药物缓释载体 

分 类 号：O63[理学—高分子化学] TQ316.3[理学—化学]