海绵Phacellia fusca中含氮化合物的分离与结构鉴定  

Four Compounds Containning Nitrogen from Marine Sponge Phacellia fusca Schmidt

作　　者：徐效华[1] 姚广民[1] 孔垂华[1] 李艳明[1] 林长江[1] 王昕[1] 苏镜娱[2] 曾陇梅[2] 

机构地区：[1]南开大学元素有机化学研究所和国家重点实验室,天津300071 [2]中山大学化学系,广州510275

出　　处：《有机化学》2003年第9期953-957,共5页Chinese Journal of Organic Chemistry

基　　金：南开大学元素有机化学国家实验室资助项目

摘　　要：从采自中国南海西沙群岛海域的海绵PhacelliafuscaSchmidt中得到 4个含氮化合物 .经1HNMR ,13 CNMR ,HMQC ,HMBC ,1H 1HCOSY ,FABMS和EIMS等光谱分析 ,确证其结构分别为 :N ,N′ 二 [2 乙氧基 1(Z) 乙烯基 ]脲 (1) ,2 Bromoaldisin (2 ) ,Aldisin (3) ,Dibromophakellin盐酸盐 (4) .其中化合物 1为一具有对称结构的新脲类化合物 ,命名PhacelliaureaA ;化合物 4是首次从该海绵中分离得到的已知胍基生物碱 ,首次报到了它的13 CNMR数据及其归属 .Four compounds containning nitrogen have been isolated from the sponge Phacellia fusea Schmidt, collected from the Xisha Islands in the South China Sea. The structures of these compounds we. re characterized by H-1 NMR, C-13 NMR, HMQC, HMBC, H-1-(HCOSY)-H-1, FA<(B)over dot>MS and EIMS as N, N'-bis[2-ethoxyl-1(Z)-vinyl] urea (1), 2-bromoaldisin (2), aldisin (3) and dibromophakellin (4). Among them, compound 1 is a new urea, containing a symmetrical partial structure, named as phacelliaurea A. Compound 4 is a known guanidine alkaloid, first isolated from the sponge Phacellia fusca Schmidt, and the data and assignments of its C-13 NMR was first reported.

关 键 词：海绵 Phacelliafusca 含氮化合物 分离 结构鉴定 生物碱 PhacelliaureaA 胍 

分 类 号：O629[理学—有机化学]