结肠定位给药系统载体偶氮聚合物合成—对甲基丙烯酰胺偶氮苯的合成与表征  

Synthesis of Azopolymer as Carriers for Colon-site Specific Drug Delivery Synthesis and Characterization of Novel Azo-crosslinker -Bis (methacryloylamino)-Azobezene for Synthesis of Azopolymer

作　　者：陈建海[1] 陈清元[1] 沈家瑞[2] 

机构地区：[1]广州第一军医大学南方医院药学部,广东广州510515 [2]华南理工大学高分子材料系,广东广州510641

出　　处：《功能高分子学报》2003年第3期319-322,共4页Journal of Functional Polymers

基　　金：国家自然科学基金课题(№39970876)

摘　　要：　为了设计与合成新的结肠靶向给药系统载体-三元偶氮共聚物,提出合成一种新的偶氮功能单体—对甲基丙烯酰胺偶氮苯[Bis(methacryloylamino) azobenzene,BMAAB]作为偶氮聚合物交联剂。BMAAB合成方法:先将对硝基苯胺氧化偶联,再还原成对胺基偶氮苯(DAAB),最后再与甲基丙烯酰氯反应。用紫外、红外、核磁共振与差热分析对产物进行了表征。In order to design and synthesize novel azopolymer as carrier for colon-site specific drug delivery, a novel azofuctional monomerbis (methacryloylamino)azobenzene (BMAAB) is presented and synthesized as an azocrosslingking agent. The synthesis pathway is that 4nitroanline was oxidized and crosslinked firstly then reduced into 4,4'diaminoazobene (4,4'DAAB). Finally reacted with methacryloyl choloride. The product is characterized by UV, FTIR, NMR and DSC.

关 键 词：结肠定位给药系统 药物载体 偶氮聚合物 合成方法 交联剂 对甲基丙烯酰胺偶氮苯 表征 

分 类 号：R944.9[医药卫生—药剂学]