科研用高纯试剂中不挥发性有机杂质分析  

Analysis of non-volatile organic impurities in high purity reagents used in scientific research

作　　者：谭和平[1] 侯晓妮[1] 邹燕[1] 周李华[1] 孙登峰[1] 

机构地区：[1]中国测试技术研究院,四川成都610021

出　　处：《中国测试》2015年第3期42-45 54,54,共5页China Measurement & Test

基　　金：国家科技部科技支撑计划项目(2012BAK25B01);国家质检公益性行业专项(201310240)

摘　　要：对国内外典型科研用HPLC级的甲醇、异丙醇和乙腈中的有机杂质进行高效液相色谱-飞行时间质谱非目标分析。实验结果表明:对每一种HPLC级高纯有机试剂而言,使用原液样品进行非目标分析时,国产试剂中有机杂质含量与进口试剂中有机杂质无显著差异;但使用原液样品的浓缩液进行非目标分析时,国产高纯试剂中的有机杂质种类远远多于国外高纯试剂中的有机杂质。这有助于了解国产HPLC级试剂与进口试剂质量差异,对提高国产HPLC试剂质量具有参考价值。Organic impurities in typical high purity reagents of domestic and foreign factories,such as methanol, isopropyl alcohol, acetonitrile, were analyzed by high performance liquid chromatography- time of flight mass spectrometry. The experimental results show that the contents of non-target organic impurities in raw samples seems to be almost equal, but after the raw samples were concentrated,the kinds of organic impurity ions in domestic samples is much more than that of foreign samples. It is of guiding significance to improve domestic HPLC reagent quality.

关 键 词：高纯试剂 杂质 甲醇 乙腈 飞行时间质谱 

分 类 号：TQ421.12[化学工程] O657.63[理学—分析化学]