MRL/lpr狼疮小鼠和C57小鼠血常规、主要脏器系数的测定与比较  

The Determination and Comparison between MRL / lpr Mice and C57 Mice Blood,Major Organ Coefficient

作　　者：杨林[1,2] 朱叶萌[1] 刘科[1] 代路路 张辰子 邝少松[1] 

机构地区：[1]广东省医学实验动物中心,佛山528248 [2]华南农业大学,广州510246

出　　处：《实验动物科学》2015年第3期44-47,共4页Laboratory Animal Science

基　　金：广东省科技计划项目(No:2013B060300033):广东省小型实验动物资源平台

摘　　要：目的测定C57小鼠与MRL/lpr转基因小鼠在4月龄、5月龄和6月龄的血常规值和脏器系数。方法用MEK-7222K全自动血液分析仪检测C57小鼠与MRL/lpr转基因小鼠血常规值。结果血常规检测方面,C57小鼠与MRL/lpr转基因小鼠相比,中性粒细胞百分率(NE%)、红细胞计数(RBC)、红细胞压积(HCT)、红细胞平均血红蛋白(MCH)、红细胞平均血红蛋白浓度(MCHC)在不同月龄的数值差异极显著(P<0.01);其中9个检测比较项目差异不显著(P>0.05)。脏器系数方面,C57小鼠的心脏系数、肾脏系数显著高于同月龄的MRL/lpr转基因小鼠(P<0.01);MRL/lpr转基因小鼠的肝脏系数显著高于同月龄的C57小鼠(P<0.01);其他比较项目差异不显著(P>0.05)。结论 C57小鼠与MRL/lpr转基因小鼠在同月龄的部分血常规数据和脏器系数差异显著。Objective To determine blood and organ coefficient values between C57 mice and MRL / lpr transgenic mice at the ages of 4 months,5 months and 6 months old. Method We used MEK-7222 K automatic blood analyzer to analyze C57 mice and MRL / lpr transgenic mice blood values. Result On the blood detection,the percentage of neutrophils( NE%), red blood cell count( RBC), hematocrit( HCT), mean corpuscular hemoglobin( MCH),red blood cells mean corpuscular hemoglobin concentration( MCHC) values in different months between C57 mice and MRL / lpr transgenic mice were significantly different( P < 0. 01); among nine items there was no significant difference compared( P > 0. 05). On organ coefficient aspects,C57 mice coefficient heart,kidneys coefficient is significantly higher than the same month-old MRL / lpr transgenic mice( P < 0. 01);MRL / lpr transgenic mouse liver coefficient is significantly higher than the same month-old C57 mice( P < 0. 01);there was no significant difference( P > 0. 05) on other comparable projects. Conclusion Partial blood and organ coefficient data were significantly different in the same months of C57 mice and MRL / lpr transgenic mice.

关 键 词：系统性红斑狼疮 MRL/lpr转基因小鼠 血常规 脏器系数 

分 类 号：R593.241[医药卫生—内科学]