粗吻海龙对去势大鼠骨质疏松作用的研究  

Effects of Trachyrhamphus Swrratus Extract on Osteoporosis of Ovariectomijed Rats

作　　者：王锦[1] 赵昕[1] 李阳[1] 李发美[2] 

机构地区：[1]沈阳军区联勤部药品仪器检验所,沈阳110026 [2]沈阳药科大学

出　　处：《中国药师》2003年第10期601-603,共3页China Pharmacist

摘　　要：目的 :研究粗吻海龙水、醇提取液对成年雌性去势大鼠所致骨质疏松症的作用。方法 :将雌性成年大鼠切除卵巢 ,8周后测定有关指标 ,并与假手术组、模型组和尼尔雌醇组进行了比较。结果 :粗吻海龙水提取液灌胃组的骨灰重、骨钙含量、骨断裂力均明显高于模型组 (P <0 .0 5 )。结论 :提示粗吻海龙提取液对去势大鼠造成的骨质疏松症有一定的治疗作用。Objective: To study an effect of Trachyrhamphus serratus extracts on ovariectomied female adult rats.Method: Water and ethanol extracts of Trachyrhamphus serratus were administered daily to the rats for 8 weeks after being ovariectomied.Then, the relative a indexes were determined and compared with the sham operation group, pattern group, and nylestriol group. Result: Statistical results showed that bone ash and calcium were sigmificantly higher in groups treated with either extract than in pattern groups(P< 0.05)and that bone strength was signidicantly in water extract treated rats.Conclusion: The study indicated that Trachyhamphus swrratus extracts have theropeutical effects on osteoporosis in ovariectomied rats.

关 键 词：骨质疏松 粗吻海龙 去势大鼠 

分 类 号：R285.5[医药卫生—中药学]