谷胱甘肽在帕金森病治疗中的研究进展  

Progress in the study of glutathione in Parkinson's disease

作　　者：胡军[1] 胡刚[1] 

机构地区：[1]南京医科大学药理学与神经生物学系，江苏南京210029

出　　处：《中国临床药理学与治疗学》2003年第5期481-484,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金项目 (№ 39970 84 6 )

摘　　要：大量研究表明过多的活性氧簇与帕金森病(Parkinson’sdisease,PD)的发生、发展密切相关。PD患者机体长期处于氧化应激状态 ,去除活性氧簇在脑内的毒性作用便成为治疗该病的一条重要途径 ,而抗氧化剂谷胱甘肽在此过程中发挥着极其关键的作用。提高谷胱甘肽在脑内的浓度或应用谷胱甘肽的类似物、前体来防治PD及其它神经退行性疾病 。In recent years, there is increasing evidence that the pathogenesis of Parkinson's disease (PD) may involve the more generation of reactive oxygen species, and investigations on patients have shown that PD is under a status of oxidative stress. The defense against the toxic effects of reactive oxygen species is an essential task within the brain. An important component of the cellular detoxification of reactive oxygen species is the antioxidant glutathione. Consequently, it seems reasonable to propose that increase of brain concentrations of glutathione including glutathione analogs or precursors could be very effective in diminishing the cumulative effects of oxidative damage, and have been investigated as potential therapeutic targets in the treatment and prevention of PD or other neurodegenerative disease.

关 键 词：药理学 综述 帕金森病 氧化应激 谷胱甘肽 神经退行性疾病 

分 类 号：R977.4[医药卫生—药品] R96[医药卫生—药学]