奥氮平对脑电图的影响  

Effects of olanzapine on electrocephalogram

作　　者：吴皓[1] 孙毅[1] 沈可芬[1] 陈虹 钱惠忠[3] 

机构地区：[1]浙江大学医学院附属邵逸夫医院神经内科,浙江杭州310016 [2]浙江省精神卫生研究院,浙江杭州310013 [3]杭州市第七人民医院,浙江杭州310013

出　　处：《中国新药与临床杂志》2003年第10期632-634,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :观察奥氮平 (olanzapine)对脑电图的影响。方法 :开放性收集门诊和住院诊断为分裂样精神障碍及精神分裂症的首诊病人 98例 ,男性 65例、女性 3 3例 ,年龄为 (3 7±s1 5 )a,病程为 (3 .6±2 .4)mo,奥氮平 (2 .5～ 1 5mg·d-1)治疗前和治疗后 8wk末分别进行脑电描记术 (electroen cephalography,EEG)描记检查 ;疗效评定用简明精神病量表 (BPRS)。结果 :经 8wk治疗奥氮平对分裂样精神障碍 (2 1例 )、精神分裂症 (77例 )疗效肯定 ,脑电图轻度异常 1 5例 ,轻～中度异常 1 1例 ,异常发生率为 2 7% ,多以慢波增多θ活动散在各导为主 ,未发现有痫样活动。临床也未见病人有抽搐发作。结论 :奥氮平治疗后脑电图异常变化有一定的发生率 ,但异常的程度低 ,不影响其临床应用 。AIM: To observe the effects of olanzapine on the el ectroencephalogram (EEG). METHODS: Ninty-eight schizophreniform disorder and schizophrenia in and out- patients 〔M,65,F,33, age (37±s 15) a and (3.6±2.4) mo〕 received olanzapine 2.5-15 mg·d -1 in routine treatment. The EEG registrations of 98 patients before and after 8 wk treatment with olanzapine (2.5-15 mg·d -1 ) were made. BPRS was ad opted to evaluate the efficacy. RESULTS: After 8 wk treatment with olanzapine, the results based on the reduct ion rate of BPRS showed olanzapine was effective on schizophrenia and schizophre niform disorder. Mild EEG abnormalities in 15 patients and mild-moderate EEG ab normalities in 11 patients were found; EEG abnormality r ate was 27%. The risk was not associated with daily dose. The EEG mainly showed theta waves with mild general changes. There were no epile ptiform EEG abnormalities during treatment with olanzapine and no seizures were found in cilinic. CONCLUSION: After treatment with olanzapine, the EEG mainly showes theta waves with mild general changes. It don't affect the clinical use of olanzapine, but the safety of long-term therapy requires further study.

关 键 词：抗精神病药 脑电描记术 精神分裂症 精神病 奥氮平 

分 类 号：R971.41[医药卫生—药品] R741.044[医药卫生—药学]