益气复智颗粒对多梗塞性痴呆模型大鼠学习记忆能力的改善作用  

Effect of Yiqi Fuzhi Granule in Improving Learning and Memory of Rats with Multi-infarct Dementia

作　　者：周建英[1] 姜春华[2] 王明艳[2] 

机构地区：[1]南京中医药大学科研处,南京210029 [2]南京中医药大学基础医学院,南京210029

出　　处：《中药新药与临床药理》2003年第5期301-304,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：江苏省教育厅自然科学基金(编号 99KJB360006)

摘　　要：目的 观察益气复智颗粒对多梗塞性痴呆模型大鼠学习记忆行为的影响。方法 采用颈内动脉注射血栓的方法,建立多梗塞性痴呆大鼠模型,观察益气复智颗粒24.84 g/kg、12.42 g/kg、6.21 g/kg灌胃对实验动物学习记忆能力的影响和脑形态学的改变。结果 益气复智颗粒能明显提高多梗塞性痴呆大鼠电迷宫测试成绩,改善脑损伤状态。结论益气复智颗粒具有较好的益智抗痴呆作用。Objective To investigate the eitect oi Yiqi Fuzhi Granule in improving learning and memory of rats with mul- ti-infarct dementia (MID). Methods MID rat models were established by embolus injection through the common carotid artery. Effects of Yiqi Fuzhi Granule(24. 84 g/kg, 12.42 g/kg, 6.21 g/kg, ig)on rat learning and memory and cerebral structure were observed. Results Yiqi Fuzhi Granule could obviously increase the scores of maze test and protect cerebral tissue from damage of multi-infarction rats. Conclusion Yiqi Fuzhi Granule has good effect in improving intellect and treating dementia.

关 键 词：多梗塞性痴呆/中药疗法 益气复智颗粒/药理学 疾病模型 动物 

分 类 号：R285.5[医药卫生—中药学]