补肾法治疗骨关节炎合并骨质疏松患者的作用机理研究  

The Mechanism Research of Kidney Invigoration on Osteoarthritis and Osteoporosis

作　　者：周丕琪[1] 沈霖[1] 杨艳萍[1] 谢晶[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院骨科研究室,湖北武汉430022

出　　处：《中国中医骨伤科杂志》2003年第5期22-24,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：卫生部科学基金资助课题 (NO:96-1-15 3 )

摘　　要：目的 :探讨补肾法对骨关节炎合并骨质疏松患者的作用机理。方法 :采用补肾中药密骨片治疗 5 0例骨关节炎并发骨质疏松症患者 ,疗程为 3个月 ,同时观察患者治疗前后症状体征、骨密度的变化 ,并检测患者血清 IL-6、TNF-α水平。结果 :在补肾中药作用下 ,患者症状及体征缓解 ,骨密度稍升高 ,血清 IL-6、TNF-α水平下降。结论 :补肾中药可能通过增加骨密度、影响细胞因子从而治疗骨关节炎合并骨质疏松患者。Objective:To probe into the mechanism of kidney invigoration on osteoarthrosis and osteoporosis.Methods:50 cases of osteoarthritis and osteoporosis were treated with Traditional Chinese medicinal drug of kidney invigoration.The course of treatment was three months. At the same time, the symptoms,signs,bone mineral density were observed in treatment before and after. The serum levels of IL-6 and TNF-α were measured.Results:It was showed that osteodynia symptoms were improved, bone mineral density was increased. The serum levels of IL-6 and TNF-α was lower than that of pretreatment.Conclusion:The Traditional Chinese medicinal drug of Kidney invigoration could increase the patients' bone mineral density and affect IL-6 and TNF-α secretion to treat Osteoarthritis and Osteoporosis.

关 键 词：骨关节炎 骨质疏松补肾法 IL—6 TNF—α 骨密度 

分 类 号：R681[医药卫生—骨科学]