Neuropilin与肿瘤血管新生  

Neuropilin and tumor angiogenesis

作　　者：李容[1] 李长辉[2] 杨纯正[1] 熊冬生[1] 

机构地区：[1]中国医学科学院.中国协和医科大学血液学研究所,天津300020 [2]中国医学科学院.中国协和医科大学药物研究所,北京100050

出　　处：《中国药理学通报》2003年第10期1093-1096,共4页Chinese Pharmacological Bulletin

基　　金：国家攀登计划 (No 95 专 10 );天津市重大科技攻关项目 (No0 0 3 1195 11)

摘　　要：Neuropilin作为轴突导向分子collapsin/semaphorin的受体在神经发育过程中引导轴突选择正确途径以成功到达靶区 ,与此同时又可作为血管内皮生长因子受体在血管新生中发挥作用。近年neuropilin在神经系统中的作用已基本得以阐明 ,而有关其在血管新生方面的研究亦有所进展 ,并且指出neuropilin参与调节肿瘤血管新生 ,在肿瘤生长转移中发挥作用。Neuropilin is a receptor both for semaphorins, which are mediators of neuronal guidance, and for VEGF, an angiogenesis factor. While the function of neuropilin in the nervous system has been characterized, its role in angiogenesis is also beginning to be elucidated. It has been shown that neuropilin and its soluble isoforms regulate tumor angiogenesis and subsequent tumor growth. This article reviews some of the structural and functional features of neuropilin and presents experimental evidences showing that it is a mediator of angiogenesis.

关 键 词：NEUROPILIN collapsin/semaphorin 血管内皮生长因子 血管新生 肿瘤 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学] R[医药卫生—基础医学] 364.3