芳香亲核取代氢反应及4-氨基二苯胺的合成  

The Nucleophilic Aromatic Substitution for Hydrogen and Its Application in the Synthesis of 4-Aminodiphenylamine

作　　者：刘腾飞[1] 王亚权[1] 

机构地区：[1]天津大学化工学院一碳化学与化工国家重点实验室,天津300072

出　　处：《化学工业与工程》2003年第5期297-302,共6页Chemical Industry and Engineering

摘　　要：芳香亲核取代氢反应是一种环境友好的有机合成反应。4-氨基二苯胺是一种重要的工业中间体,在它的合成过程中对环境污染严重。Flexsys公司将芳香亲核取代氢反应应用于4-氨基二苯胺的合成,解决了环境污染问题。并因此荣获1998年度美国总统绿色化学挑战奖。本文介绍了4-氨基二苯胺的传统合成方法,进而又介绍了芳香亲核取代氢反应的机理及其在4-氨基二苯胺合成中的应用。The nucleophilic aromatic substitution for hydrogen reaction is an environmentally benign organic synthesis reaction.4-aminodiphenylamine is an important industrial intermediate.In its synthesis process the pollution is very serious.Flexsys company applied the nucleophilic aromatic substitution for hydrogen reaction to the synthesis of 4-aminodiphenylamine and solved the pollution problem.For this contribution,they were awarded the 1998 Presidential Green Chemistry Challenge Prize.The traditional synthesis methods of 4-aminodiphenylamine,the mechanism of nucleophilic aromatic substitution for hydrogen reaction and the application of nucleophilic aromatic substitution for hydrogen in the synthesis of 4-aminodiphenylamine were reviewed.

关 键 词：芳香亲核取代氢反应 4-氨基二苯胺 合成 绿色化学 

分 类 号：O625.631[理学—有机化学]