抗痨颗粒剂对家兔气管纤毛运动速度的影响  

The Effect of Kanglao Granula on the Rabbit's Trachea Cilia Moving Speed

作　　者：张卫红[1] 李克[1] 秦俊莲[1] 

机构地区：[1]河南中医学院

出　　处：《河南中医学院学报》2003年第5期28-29,共2页Journal of Henan University of Chinese Medicine

基　　金：河南省计划经济管理委员会重点课题 (94 - 4 - 7- 5 1 )

摘　　要：目的 :研究抗痨颗粒对气管纤毛运动的影响 ,探讨其“敛肺止咳 ,清热化痰”的作用机理。方法 :采用家兔在体气管试验 ,设乙酰胆碱组和抗痨颗粒剂低、高剂量组。乙酰胆碱组用乙酰胆碱 1 0 0mg kg肌注 ,抗痨颗粒剂低剂量组用 1 5 g kg灌胃 ,高剂量组用 30 g kg灌胃。在戊巴比妥钠静脉麻醉后 ,切开颈部 ,暴露气管 ,在下段用 0 .2 5ml注射器注入印度墨汁 ,观察墨汁运动速度 (mm min)。结果 :抗痨颗粒剂低剂量组和高剂量组在给药后 30min、6 0min、90min、1 2 0min时增快 ,1 5 0min时减慢 ;而乙酰胆碱组在给药后 30min、6 0min时增快 ,90min时则减慢。结论 :抗痨颗粒剂具有促进气管纤毛运动的作用 。Objective: To study the effect of this granula on trachea cilia movement and its mechanism on relieving cough with drugs of astringent effect to the lung, and clearing away heat and dispersing phlegm. Method: Conduct trachea cilia movement test in vivo on rabbits. Set up acetylcholine group intramuscularly injected with 100% acetylcholine, low dose group and high dose group respectively given 15 g/kg and 30 g/kg of this granula for gastric perfusion. After pentobarbital vein anesthesia, cut the rabbit's neck to expose the trachea. Inject Indian ink at low segment of the trachea using 0.25 ml injector. Guide the light with fiber and special electric torch and measure the ink moving speed (mm/min) on the wall of trachea with a stopwatch and a compass. Results: Of the low dose group and high dose group, at 30 min, 60 min, 90 min and 120 min after treatment the cilium moving speed increased, at 150 min the moving speed decreased. Of the acetylcholine group, at 30 min and 60 min after the treatment, the cilium moving speed increased, at 90 min, the moving speed decreased. Conclusion: Kanglao Granula can promote the trachea cilia movement and this is gentler and lasts longer than acethlcholine.

关 键 词：抗痨颗粒剂 气管 纤毛运动 在体试验 

分 类 号：R285.6[医药卫生—中药学]