生脉注射液的稳定性研究  

STUDY ON THE STABILITY OF SHENGMAI INJECTION

作　　者：宋庆臣 张巍[2] 

机构地区：[1]汶上县人民医院,山东汶上272500 [2]临沂市人民医院

出　　处：《临沂医学专科学校学报》2003年第4期251-252,共2页Journal of Linyi Medical College

摘　　要：目的　 研究生脉注射液的化学稳定性 ,为保证药效提供依据。方法　 采用初均速法 ,分别在 4 0、5 0、6 0、70、80、90℃ (± 1℃ )下 ,恒温加热不同时间 ,用高效液相色谱法测定生脉注射液各样品的峰面积。结果　 相关系数r =- 0 .976 9,说明LgVo与 1 T的线性关系良好 ,符合一级动力学公式。结论　 生脉注射液的热解反应活化能为 2 1.10 6kcal mol,以Arrhenius指数规律推算t3 0℃0 .9贮存期为 1.7a ,t2 5℃0 .9贮存期约为 3a。Objective To study the stability of shengmai injection.Methods According to the initial average rate method,samples were heated at the constant temperatures of 40,50,60,70,80,90,(±1)℃.The peak areas were measured with high performance liquid chromatography.Results The coefficient r of being 0.9769 indicated that there existed a good linearity between LgVo and 1/T,conforming to the first-order dynamic formula.Conclusion The activation energy of pyrolysis reaction is 21.101Kcal/mol.The storage time is 1.7a in 30℃ stockpile and 3a in 25℃stockpile.

关 键 词：生脉注射液 稳定性 贮存期 

分 类 号：R965[医药卫生—药理学]