慢性病毒性肝炎PCIII HA及Ln检测的临床意义  

THE DETECTION AND ITS CLINICAL SIGNIFICANCE OF TYPE III PROCOLLAGEN,HYALURONIC ACID AND LAMININ IN CHRONIC VIRUS

作　　者：马建民[1] 薛桂芹[2] 

机构地区：[1]临沂医学专科学校,山东临沂276002 [2]临沂市人民医院

出　　处：《临沂医学专科学校学报》2003年第4期253-254,共2页Journal of Linyi Medical College

摘　　要：目的　 探讨慢性病毒性肝炎血清纤维化指标III型前胶原 (PCIII) ,透明质酸 (HA)及层粘蛋白 (Ln)水平与肝纤维化程度的关系。方法　 采用放射免疫分析法测定 80例慢性病毒性肝炎患者血清PCIII、HA及Ln的水平。结果　 发现PCIII、HA及Ln的水平在重度慢性病毒性肝炎中均明显升高 ,与轻、中度及正常对照组相比具有显著差异 (P <0 .0 1) ,PCIII与Ln在轻度与正常对照组相比无显著差异 (P >0 .0 5 ) ,HA含量在轻、中度和正常对照组相比较有显著差异 (P <0 .0 5 )。结论　 对慢性病毒性肝炎PCIII、HA及Ln的检测 ,从不同角度反映了肝纤维化的严重程度 ,避免了肝脏病理活检的创伤 ,对慢性病毒性肝炎病程发展的估计。Objective To study the relationship between level of Type III procollagen (PCIII),hyaluronic acid (HA),laminin(Ln) and hepatic fibrosis.Methods These three serum components were measured in 80 patients with chronic virus hepatitis by radioimmunoassay.Results The contents of serum PCIII,HA and Ln in severe cases of chronic virus hepatitis were notably higher than in cases of mild and moderate chronic hepatitis and healthy controls(P<0.01).The contents of PCIII and Ln in mild and moderate cases of chronic hepatitis showed no significant difference(P>0.05),while the contents of them and those of the control group revealed marked significance (P<0.05).Conclusion The detection of serum level of PCIII,HA and Ln in chronic hepatitis can reveal the degrees of hepatic fibrosis to avoid the wounds from liver biopsy,and can be of great importance in estimating the state of hepatitis as well as prognosis.

关 键 词：Ⅲ型前胶原 透明质酸 层粘蛋白 慢性病毒性肝炎 

分 类 号：R512.6[医药卫生—内科学]